NR cost per dose
What does a trial dose of NR cost? In one trial, 1,000 mg a day raised blood NAD+ 142%
Renue's NR powder and capsules, compared at the trial dose. In an 8-week trial of healthy overweight adults, 1,000 mg a day raised whole-blood NAD+ 142%.
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Article info
Evidence: 8 papers, 6 human studies, 2 reviews.
Research and article information
How we made this. Checked against every study we cite. It is not medical advice.
Updated:
How we check · Methodology · Is NMN legal in US supplements? · Corrections · How we’re funded
142%
rise in whole-blood NAD+ on 1,000 mg of NR a day, held through an 8-week trial
Bottom line
In an 8-week randomized, double-blind, placebo-controlled trial of healthy overweight adults, 1,000 mg of nicotinamide riboside (NR) a day raised whole-blood NAD+ by 142% within two weeks, the largest rise of its 100, 300 and 1,000 mg tiers, and the rise held to the end of the trial (Conze 2019). To reach that dose, Renue’s NR Powder serves 1,000 mg in one two-scoop serving; its liposomal capsule (Lipo NR) holds 300 mg, so three capsules make 900 mg, the closest whole-capsule amount. See NR Powder and Lipo NR on Renue’s site.
The studies ran from 3 weeks to 10 weeks
Elhassan 2019 1,000 mg a day
3 weeksMeasured: skeletal-muscle NAD+ metabolome
Vreones 2023 500 mg twice a day
6 weeksMeasured: NAD+ in neuron-enriched plasma vesicles
Conze 2019 1,000 mg a day
8 weeksMeasured: whole-blood NAD+
Orr 2024 1,000 mg a day (final dose, after escalation)
10 weeksMeasured: blood NAD+
Figure 1. The dose each human trial used and how long it lasted, as its abstract reports. Longer bars mean longer trials.
Source: Healthspan Post summary of the cited trials (PubMed).
What a trial dose costs
Two label numbers turn a price into a cost per trial dose: the amount per serving and the servings per container. Prices change, so check the live prices through the link below the table. Divide a container’s price by the days it lasts at a given dose; the lower result is the cheaper way to that dose.
The doses come from Conze 2019, which gave 100, 300 or 1,000 mg a day. Two smaller crossover trials in older people also used 1,000 mg a day: it raised the muscle NAD+ metabolome in 12 aged men over 21 days (Elhassan 2019) and NAD+ in neuron-enriched plasma vesicles in 22 healthy older adults over 6 weeks (Vreones 2023).
| Trial dose (Conze 2019) | Whole-blood NAD+ in the trial | Renue serving that matches | Days per container |
|---|---|---|---|
| 1,000 mg a day | +142% within 2 weeks, held to 8 weeks | NR Powder Smooth Taste Blend: 1 two-scoop serving (1,000 mg) | 60 (60 servings) |
| 1,000 mg a day | +142% at 1,000 mg (900 mg was not tested) | Lipo NR: 3 capsules (900 mg, the closest whole-capsule amount) | 30 (90 capsules) |
| 300 mg a day | +51% within 2 weeks, held to 8 weeks | Lipo NR: 1 capsule (300 mg) | 90 (90 capsules) |
| 100 mg a day | +22% within 2 weeks, held to 8 weeks | No matching serving (one capsule is 300 mg) | - |
Price per serving
| Product | Form | Per serving | Servings | Price | Cost per serving | Cost per 500 mg |
|---|---|---|---|---|---|---|
 NR Powder Smooth Taste Blend1,000 mg of nicotinamide riboside chloride per two-scoop serving, 60 servings per jar: 60 days at the 1,000 mg trial tier. See the price table for cost per day. | powder | 1,000 mg | 60 | $79.00 | $1.32 | $0.66 |
 Lipo NR Liposomal Capsules300 mg of nicotinamide riboside per capsule, 90 capsules per jar: 90 days at the 300 mg tier, or 30 days at three capsules (900 mg) a day. See the price table for cost per day. | liposomal capsule | 300 mg | 90 | $64.95 | $0.72 | $1.20 |
One-time purchase prices from Renue By Science, checked November 12, 2026. Prices change; the store shows the current one. Cost per 500 mg uses the main active ingredient.
The product note
Renue sells NR in two forms. NR Powder Smooth Taste Blend serves 1,000 mg of nicotinamide riboside chloride per two-scoop serving, 60 servings per jar; Renue says it is a citrus powder that dissolves easily, to take under the tongue or mix into water or a drink. Lipo NR holds 300 mg of nicotinamide riboside per capsule, 90 capsules per jar, in liposomes that Renue says protect it through digestion for slower release. Renue says NR is one of the most studied ways to support healthy NAD+ levels. Compare NR Powder and Lipo NR on Renue’s site.
Figure 2. NMN sits one step from NAD+ in the salvage pathway, the main route cells use to keep NAD+ topped up.
Source: Covarrubias et al., Nature Reviews Molecular Cell Biology, 2021 (PubMed 33353981).
What we checked
- Lab result vs label
- No report Renue lists no test report for this product.
- Cost per 500 mg
- $0.66
- Where it sits in Renue's NR range, cost per 500 mg
This product Same-molecule products · USD per 500 mg · Prices checked November 12, 2026
Products and prices
- NR Powder Smooth Taste Blend: $0.66
- Lipo NR Liposomal Capsules: $1.20
- Human studies in this article
- 6 5 randomized trials (study design grade A)
Certificates checked October 10, 2026: we read the certificates of analysis Renue publishes and none is listed for this product yet; we don't run lab tests ourselves. Every report we checked · Price index
Show the scienceStudy-by-study table: 8 studies, design, dose and grade
The evidence
Every study cited in this article. Grades: A human RCT, meta-analysis or systematic review; B small, pilot or observational human study.
| Study | Design | People | Dose / duration | Result | Grade | Source |
|---|---|---|---|---|---|---|
| Conze 2019[1] | RCT | Healthy overweight adults | 100, 300 or 1,000 mg a day · 8 weeks | Whole-blood NAD+ rose 22%, 51% and 142% within 2 weeks and held to 8 weeks; no flushing; adverse events no different from placebo | A | PubMed 31278280 |
| Martens 2018[2] | RCT | Healthy middle-aged and older adults | 2 x 6 weeks (crossover) | Chronic NR well tolerated; stimulated NAD+ metabolism | A | PubMed 29599478 |
| Vreones 2023[3] | RCT | Healthy older adultsn = 22 | 500 mg twice a day · 6 weeks | Oral NR raised NAD+ in neuron-enriched plasma vesicles | A | PubMed 36515353 |
| Elhassan 2019[4] | RCT | Aged menn = 12 | 1,000 mg a day · 21 days | Raised the muscle NAD+ metabolome and lowered circulating inflammatory cytokines; mitochondrial bioenergetics unchanged | A | PubMed 31412242 |
| Orr 2024[5] | pilot | Older adults with mild cognitive impairmentn = 20 | 1,000 mg a day (final dose, after escalation) · 10 weeks | Blood NAD+ rose 2.6-fold; cognition scores remained stable | B | PubMed 37994989 |
| Norheim 2024[6] | RCT | Patients with stable COPDn = 40 | 6 weeks (12-week follow-up) | Whole-blood NAD+ more than doubled | A | PubMed 39548320 |
| Gallagher 2026[7] | systematic review | 113 studies (33 human, 28 of them randomized; 80 rodent) | NR and NMN, oral or parenteral · weeks to months | In humans, oral NR and NMN consistently raised NAD-related markers and were generally well tolerated; functional, metabolic and vascular outcomes heterogeneous and often null | A | PubMed 41655607 |
| Prokopidis 2025[8] | meta-analysis | Adults in randomized trials, mean age 60.9-83 | not reported | NR linked to a longer 6-minute walk in peripheral artery disease and lower physical-performance scores in mild cognitive impairment; NMN no significant effect on muscle index, handgrip or gait speed | A | PubMed 40275690 |
Questions readers ask
How much NR did the trials use to raise blood NAD+?
In an 8-week randomized trial of healthy overweight adults, 100, 300 and 1,000 mg of NR a day raised whole-blood NAD+ 22%, 51% and 142% within two weeks, and the rises held to the end of the trial. Source PubMed 31278280
How many servings reach the 1,000 mg dose the trials used?
NR Powder serves 1,000 mg per two-scoop serving, so its 60 servings last 60 days at one a day. Lipo NR is 300 mg per capsule: one capsule a day matches the 300 mg tier for 90 days, and three capsules a day make 900 mg, close to the 1,000 mg tier, for 30 days per jar.
Does a 1,000 mg dose of NR work better than 300 mg?
For blood NAD+, yes: in an 8-week randomized trial, 1,000 mg a day raised whole-blood NAD+ 142% against 51% at 300 mg, with no significant difference in adverse events between doses or against placebo. That trial reported NAD+ and safety measures, not energy or performance. Source PubMed 31278280
Which NR product is the cheaper way to 1,000 mg a day?
Divide each jar's current price on Renue's site by its days at the top tier: 60 for NR Powder at 1,000 mg a day, and 30 for Lipo NR at three capsules (900 mg) a day. The lower figure is the cheaper daily amount.
NR Powder Smooth Taste Blend: the trade-offs
Why people choose it
- 1,000 mg nicotinamide riboside chloride per 2-scoop serving
- Sweet orange flavour; mix into water or take under the tongue
- 60 servings per bottle
Things to know
- Flavoured blend, not plain NR
- NR and NMN are different molecules, so their doses are not interchangeable
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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References
View all 8 cited studies
- Conze D, Brenner C, Kruger CL (2019). Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep. PubMed 31278280
- Martens CR, Denman BA, Mazzo MR, et al. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. PubMed 29599478
- Vreones M, Mustapic M, Moaddel R, et al. (2023). Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin. Aging Cell. PubMed 36515353
- Elhassan YS, Kluckova K, Fletcher RS, et al. (2019). Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Rep. PubMed 31412242
- Orr ME, Kotkowski E, Ramirez P, et al. (2024). A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment. Geroscience. PubMed 37994989
- Norheim KL, Ben Ezra M, Heckenbach I, et al. (2024). Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial. Nat Aging. PubMed 39548320
- Gallagher C, Emmanuel OO (2026). NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence. Ageing Res Rev. PubMed 41655607
- Prokopidis K, Moriarty F, Bahat G, et al. (2025). The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis. J Cachexia Sarcopenia Muscle. PubMed 40275690